CBD basic knowledge
Introducing the basic knowledge of CBD, frequently asked questions from customers.
3 types of CBD oil
Full spectrum CBD oil : As the name implies, full spectrum CBD oil contains all cannabinoids.Full spectrum CBD oil is a euphoric ingredientSince THC is also included, it is prohibited in Japan.
Broad Spectrum CBD Oil:Broadspectrum CBD oil contains all cannabinoids other than THC.Broadspectrum CBD oil does not contain THC, soDistribution in Japan is permitted by law.
Isolate CBD Oil:Isolate is a condensed CBD alone.Isolate CBD oil is made by adding isolate to MCT oil to adjust the concentration.Isolate CBD oil contains no cannabinoids other than CBD.Isolate CBD oil is mainly used by athletes.Because cannabinoids other than CBD are still banned by WADA (World Anti-Doping Agency). CBD alone was removed from the WADA (World Anti-Doping Agency) ban list in 2018.
Only isolate and broad spectrum can be sold in Japan, but in Japan it seems that broad spectrum is often called full spectrum.In Japan, where the sale of full spectrum CBD oil is bannedBroadspectral CBD oil is often referred to as full spectrum CBD oil.
Well, this is generally not well known, but ...There are actually two types of broad spectrum above.The difference is whether you are using isolate or not.
Mixing hemp oil with isolate gives a broad spectrum.Hemp oil also contains other cannabinoids, albeit in very small amounts.But,Inexpensive hemp oil with few cannabinoidsIt doesn't make much sense to add isolate to. Since cannabinoids other than CBD are originally contained in a very small amount, adding isolate to low-concentration hemp oil does not expect much of the original broad spectrum anthrage effect.It's reasonable to think that this type of Broad Spectrum CBD oil is mixed with hemp oil rather than MCT oil to claim Broad Spectrum.
Another Broad Spectrum CBD oil is non-isolated.This is from the beginningHigh concentration of CBD hemp oilThe concentration is adjusted by diluting with MCT oil or coconut oil.In other words, all cannabinoids are in a natural balance.This is the highest level of CBD oil available in Japan.
What is the entourage effect?
If you take only CBD, it will be absorbed as you increase the amount up to a certain amount.However, when the limit value is reached, the phenomenon that the absorption rate decreases conversely occurs.This reactionBell-shaped dose-response of single CBDIt is called.
But there is a way to overcome this.ItEntourage effectIt's called.Entourage effect Is a phenomenon that enables absorption of cannabinoids other than CBD, terpenes, flavonoids, and other components at the same time, which exceeds the conventional limit of CBD.
Entourage effect Occurs not only in CBD, but also in other cannabinoids.Rather than ingesting CBD alone or CBG alone, various components extracted from hemp are intertwined, making it possible to ingest beyond the limits of a single substance.The various ingredients are interrelated and maximize each other's strengths.
About Ministry of Health and Welfare approval
“Approved by the Ministry of Health and Welfare”I often see it on the CBD sales site.I would like to explain a little about the approval of the Ministry of Health and Welfare.To import CBD products into Japan, the Ministry of Health and Welfare must review the documents.The contents of the document examination will be a certificate made only from stems and seeds, photographs and certificates of the manufacturing process, ingredient list, etc.In other words, all legal CBD products sold domestically are licensed by the Ministry of Health.The Ministry of Health and Welfare is an organization that examines documents and does not perform any inspections. All products sold by CBD Medica have been tested for ingredients by a third party in the United States.Furthermore, even in Japan, again after importing the product. Japan Cannabidiol Association tests our products. We only ship and sell products that have been inspected and certified.
How to calculate amount of CBD ingestion
Manufacturers who use 10ml bottles often write in percentage. 10% of 100ml is 10000mg.As an example, 20% means that 10ml contains 2000mg.
In the case of manufacturers that use 30ml bottles, it is difficult to understand by calculation from%, so it seems that there are many mg notations instead of percentages.As an example, if 30 ml is 1000 mg, then 1000 mg ➗ 30 ml = 33.33 mg / 1 ml.Since there are differences depending on the dropper, if you count the number of drops of 1 ml, you can calculate how many mg of CBD is contained in each drop. The dropper of CBD Medica is about 1 drops per ml, so in this case 40 ➗ 33.33 = 40 mg per drop.
Why CBD is so expensive
A lot of hemp is needed to make CBD oil.It costs a lot of money to grow, harvest, and manufacture hemp over a long period of time.In particular, CBD oil for Japan is legally only allowed to use hemp seeds and stems, so it requires a larger amount of hemp than products from other countries.This is why Japanese CBD products are especially expensive in the world.
What is hemp?
Hemp has a long history and has been widely used by humankind for more than 4,000 years.
The leaves and spikes contain THC (euphoric ingredient), and a large amount of CBD is extracted from the stems and seeds.This product is manufactured from stems and seeds only.
What is CBD <cannabidiol>?
Hemp contains more than XNUMX different compounds.It contains terpenes, flavonoids, phenols, cannabinoids, etc.
Among them, there are more than XNUMX types of cannabinoids, which are physiologically active substances, and CBD is one of the most promising phytonutrients that are being researched every day around the world.
What is cannabinoid?
Cannabinoids are bioactive substances that exist in the body of mammals, including us humans.Also called an endogenous cannabinoid.Endogenous cannabinoids have receptors and receptors that accept them, including CB1 receptors in the nervous system and CB2 receptors in the immune system.
Why cannabinoids are attracting attention
Cannabinoids are attracting worldwide attention because of the recent discoveries and reports of various uses of CBD through research.
CBD research and experiments are conducted daily around the world.
In January 2018, the World Health Organization (WHO) officially announced the usefulness of the cannabidiol (CBD) component, and the Anti-Doping Agency (WADA) also announced that it would exclude cannabidiol (CBD) from the banned drug designation. Did.
About the endocannabinoid system
The endocannabinoid system is a body regulation function.This system is said to be found in all vertebrates, including humans, animals and birds.Recently, it is known that earthworms and leeches also have it.
Originally, all vertebrates, including us, make cannabinoids in their bodies.
This is called an endogenous cannabinoid.
The endocannabinoid system binds endogenous cannabinoids to cannabinoid receptors and directs the body to regulate physical function.
Assuming the cannabinoid receptor is the keyhole, the cannabinoid is the key.
Previously, cannabinoid receptors were thought to be found only in the brain and nerves, but recent studies have shown that the receptors are found in the skin, immune cells, bones, adipose tissue, liver, pancreas, skeletal muscle, heart, blood vessels, It has been shown to be present throughout the body, including the kidneys and digestive tract.
What is cannabinoid deficiency?
It is said that there are two types of cannabinoid deficiency.Cannabinoid deficiency is currently a hypothesis and has not been fully substantiated, but much evidence has been published worldwide.
One is for people who are genetically less likely to secrete endogenous cannabinoids.
The other is when the cannabinoids produced by the body decrease with age and cannabinoids are deficient.
By binding the endocannabinoids and cannabinoid receptors that are originally produced in the body, it gives instructions to regulate the body's functions in the body.
It is said that cannabinoid deficiency makes these adjustments difficult and is one of the causes of many physical function problems.
What is the difference between supercritical hemp oil and ethanol-extracted hemp oil?
There are two production processes for phytocannabinoid rich hemp oil(PCR) at Folium Biosciences.First, there is a process that uses supercritical CO2.It extracts high concentrations of terpenes, cannabidiol (CBD), and other cannabinoids.Moreover, ethanol and solvent are removed from the extract through further dewaxing using vacuum distillation.The result is PCR hemp oil, which contains 2-70% CBD and other cannabinoids and terpenes, with THC, chlorofil, and excess oil removed.
In the second extraction step, ethanol is used as the solvent.After that, THC, chlorofil, and excess oil are removed by the same refining method as the process using supercritical CO2.The only difference between the two processes is the solvent used.The first step uses CO2 and the second step uses ethanol.
The main components of hemp oil (CBD, as well as other cannabinoids and terpenes) remain the same in both steps.Since both processes use the same refining process, the final product of hemp oil has the same ingredients.
Regardless of the extraction solvent, both processes guarantee the same quality and composition.
Is it okay to give my child CBD oil?
CBD oil can also be used by children.Children should start with a small amount of CBD 250mg.
There are very rare cases of allergies.If you are new to us, we recommend that you try with a limited amounts.
Oral intake and gastric absorption of CBD
CBD is recommended for sublingual mucosal absorption.Ideally, it should be hung under the tongue and kept in the mouth for a long time in order to absorb all the ingredients more efficiently.If swallowed immediately, it mixes with saliva and is absorbed from the stomach.In that case, it takes time to absorb and the absorption rate decreases.In particular, most cannabinoids other than CBD, which are present only in trace amounts, are not absorbed, and it is thought that expectations for the entourage effect are diminished.
Timing of ingestion
As you deepen your understanding of the endocannabinoid system, you will find that the function of CBD varies from person to person.
For sleep, for example, CBD doesn't make everyone sleepy.On the contrary, depending on the person's physical condition and constitution, there are some people who have clear eyes and cannot sleep.
If you think you should take it at night, try it right after you wake up in the morning.I think that many people feel that it is completely different from the night.The correct way to take CBD is to decide the time of intake according to the physical condition of the day.
If you're new to CBD, we recommend starting with a small amount.This is an important procedure to check if allergic reactions occur.
If there are no problems, we recommend that you gradually increase your intake to the appropriate amount.I think it's a good idea to keep a CBD journal to determine your intake.
The ideal intake depends on the person's weight, past cannabinoid use history, metabolic capacity, pharmacological resistance, genes, individual differences in cannabinoid receptors, route of administration, medical disease, etc. The recommended intake based on is not established and varies from person to person.
The ideal intake of CBD varies from person to person.
Recommended intake based on medical evidence, as the effect varies depending on body weight, past cannabinoid use history, metabolic capacity, pharmacological resistance, genes, individual differences in cannabinoid receptors, route of administration, medical disease, etc. Has not been established and varies from person to person.
CBD is very expensive.Isn't it very important to get more benefits with smaller amounts for long-term cost control?It's a bit of a hassle, but why not add a CBD journal to find out your ideal intake?It's easy, but I'll show you how to add a CBD journal.
We recommend that you keep a weekly CBD journal.Start with a small amount and gradually increase until you feel the change.
Week 1: Try taking 2 mg of CBD at a time, 1 times daily.
2nd week: If there is no change in the 1st week, try increasing 2mg once in the 4nd week to 1 times a day.
Week 3: Suppose you feel a change in the second week.Then, in the 2rd week, increase it a little more and take 3mg once a day, 5 times a day.
Week 4: Assuming better results in Week 3, add a little more in Week 4 and try increasing 6 mg at a time, 1 times a day.
Week 5: Suppose there was no further change in Week 4.Now return the dose to 5 mg.This is your sweet spot.
Since there are individual differences in the initial amount and the amount to be increased, the above amount should be considered as an example.For example, if there is no change in the 3rd week, you can increase it from 4mg to 5mg or 8mg once in the 10th week.
CBD has no dependencies. It is believed that one of the biggest reasons the WHO (World Health Organization) has removed CBD from the list of controlled drugs is non-dependency.
Recent studies suggest that it can be used to treat addiction rather than being addictive.
Recent human and animal studies suggest that CBD may reduce the addictive desires of tobacco, heroin, cocaine, and cannabis itself.
Do CBD Have Side Effects?
Currently, scientific studies have not reported any serious side effects even at high concentrations of 2000 mg daily.
For reference, the average person's intake is 10 mg to 50 mg daily.The above 2000mg is 40 to 200 times this general daily intake.
Bioavailability is an indicator of how well an administered drug or formulation, in this case CBD, reaches and acts in the systemic circulation. “Bio” means biological and “availability” means availability. The combined amount of the two is shown as a biologically available amount.
The rate of bioavailability is expressed as the extent of bioavailability and the rate of bioavailability as the rate of bioavailability.
The bioavailability of creams such as vapors, oils, edibles, and balms is as follows:
Vape / Lung absorption: 30% -50%
Oil / sublingual absorption: 12-35%
Edible / gastric absorption: 4-20%
Cream / transdermal absorption: unconfirmed
Edibles, capsules, softgels
The bioavailability of edibles such as gummies, capsules, softgels, and (stomach absorption), which are popular these days, is 4% to 20%, which is lower than that of stomach absorption and lung absorption. It is said that when CBD and other cannabinoids are swallowed, they pass through the digestive system, and many cannabinoids are decomposed and destroyed by liver enzymes at that time.The disadvantages are that the bioavailability is low, so the cost is a little high, and it is difficult to fine-tune the intake, but to absorb more cannabinoids in this way, you should take a larger amount. ..
Stomach absorption takes the longest time to work on the body, but it also has the great advantage of being absorbed slowly and lasting for a long time.
CBD cream massage oil, dermal patch
The bioavailability of skin absorption is said to be lower than lung absorption, sublingual absorption, and gastric absorption.However, this is just the amount that reaches the bloodstream, and there is no problem with using it directly on the skin itself.The advantage of applying it directly to the skin is that it can be delivered pinpointly wherever you are concerned.
The popularity of CBD creams, balms, and massage oils has skyrocketed recently.Many CBD manufacturers aim to reduce skin irritation and improve muscle aches by adding Arnica or essential oils to CBD cream.There are many reports that muscle inflammation was actually suppressed, but this is thought to be a placebo effect.
Recent studies have shown that CBD does not penetrate beyond the skin layer to the muscles and joints below it.Water-soluble, nano-products seem to be ideal for penetration into muscles and joints.
Unless it's a water-soluble or nano-product, CBD cream seems to be best used for the skin, not for muscles and joints.If you use it for muscles and joints, it is effective to deliver CBD to the blood by sublingual or gastric absorption.
To improve low bioavailability, many researchers are now researching innovative absorption methods on a daily basis.One of them is the skin patch (Dermal patch) that I have seen recently. The advantage of CBD skin patches is that they slowly penetrate into the body over time.The time is said to be 12 to 92 hours, which has the advantage of preventing you from forgetting to take it, but you also need to be careful.Dermal patch was originally developed as a pharmaceutical product.Simply applying CBD oil to the patch does not increase penetration or bioavailability.Permeable enhancers need to be added to increase bioavailability, penetrate under the skin, and deliver CBD to the bloodstream. If you use CBD patches, we recommend that you check with the manufacturer to see what techniques are used to penetrate the skin.
About the advantages and disadvantages of Vape, and precautions
The bioavailability of vapor / lung absorption is 30% to 50%, which is very high and has immediate effect, which is the biggest merit.A bioavailability of 30-50% means that 30% to 50% of the inhaled CBD reaches and acts in the systemic circulation.
It is by far the best compared to 12-35% of oil / sublingual absorption and 4-20% of edible / gastric absorption.
In addition, one of the great merits is that it can be used easily and quickly, and that there are a wide range of ways to enjoy it by adding terpenes and seasoning.However, at the same time as these benefits, many questions have been raised about safety.In the United States, more than 1000 cases of physical disorders and serious problems such as pneumonia caused by vapor have been reported.Taking CBD, which suppresses inflammation, causes pneumonia, isn't it?
Now let's dig a little deeper into the disadvantages and caveats.
First of all, it is difficult to control the intake.It's very difficult to know how many mg of CBD you can get with a single dose of vapor, and you're always conscious of how many puffs you have to inhale to get the ideal daily intake, and what puffs you have right now. Isn't it very difficult to do?
Next, regarding toxicity, some types of vapor liquids are toxic.For example, MCT oil and E-liquid vitamin E acetate. MCT oil is harmless for sublingual absorption and gastric absorption, but caution is required as it is toxic when inhaled as vapor and may cause pneumonia.Therefore, it is definitely not recommended to use CBD oil for sublingual absorption in the vapor.Let's use a liquid exclusively for Vape ??
VG (propylene glycol) and PG (vegetable glycerin) are mainly used for the liquid for exclusive use of vapor, but the flavor added to these also has the possibility of adversely affecting the lungs depending on the substance. You can not.It is important to choose flavors that are as natural as possible and that use materials that are safe to inhale, and if possible, liquids that are manufactured by an independent lab-tested manufacturer.
Now let's talk a little about the body of Vape.
Recent research has shown that heavy metals such as aluminum, calcium, chromium, copper, iron, lead, magnesium, nickel, silicon, tin, and zinc may be generated from the coils of high-voltage tank-type vapor bodies. I know.
It is also known that the coil may slowly decompose and oxidize to generate heavy metal nanoparticles if it is used for a long period of time from a vapor pen or the like.If you use Vape, we recommend that you purchase it at a reliable shop and replace the coil part regularly.For example, it is not recommended to reuse disposable vapors many times or to use them beyond the usage limit.When the coil gets old, buy a new one.
About Isolate CBD Oil
Isolate CBD oil is a CBD oil made by blending 97% to 99% condensed CBD with MCT oil.The isolated CBD itself, also known as pure CBD, is a single CBD only and contains no (shouldn't) any other cannabinoids.
In 2018, WADA (World Anti-Doping Agency) removed CBD from the ban list.As a result, isolated CBD oil has become widely used mainly in athletes and competitive sports.It's important to note that only CBD (cannabidiol) was excluded from the ban list, and non-CBD cannabinoids such as CBG, CBN, and CBDv are still on the ban list.Those who are engaged in competitive sports such as doping tests can only use isolated CBD oil, not Broad Spectrum.Also, even oils that use CBD isolate must be used at your own risk after carefully checking the ingredient list.Athletes can rest assured that they will use products from major, trusted manufacturers that have published ingredient lists.
It is important to note that even with isolated oils, so-called fake broad spectrum products, such as those that later add other cannabinoids, will also be caught in the doping test.
The advantage of isolated CBD oil lies in its price.Isolate CBD has the advantage of being reasonably priced because it is considerably cheaper than Broad Spectrum.However, there are some disadvantages.
If you take only CBD, it will be absorbed as you increase the amount up to a certain amount.However, when the limit is reached, the absorption rate drops.This reaction is called the bell-shaped dose response of simple substance CBD.So, to use CBD Isolate Oil, you need to pinpoint your sweet spot, the limit.
If you want to get more effect, you need to use broad spectrum or full spectrum (illegal in Japan).
Considering cost performance, the price will be a little higher, but Broad Spectrum is still recommended.
About allergies to MCT oil
BD Medica uses coconut-derived MCT oil.
Coconut allergy is said to have the least allergic symptoms and a small number of patients among nuts.However, it is not completely free of allergies.Serious allergic reactions, such as oral allergy syndrome, rarely occur.If you have allergies and are eating for the first time, we recommend that you consult your doctor before using.
There are many sites and products that only mention "MCT oil" as CBD oil sold in Japan.If you have allergies, we recommend that you always check the brands and shops for any allergens.
For other questions, please contact us from the inquiry form.